TPX-0131

Chemical Properties

Density	1.56±0.1 g/cm3(Predicted)
storage temp.	Store at -20°C
solubility	DMSO:25.0(Max Conc. mg/mL);55.88(Max Conc. mM)
form	Solid
pka	10.52±0.60(Predicted)
color	White to off-white
InChIKey	ILAMRXVQSGVCJX-WDHUHKLTNA-N
SMILES	C([C@@H]1COC2=CN3N=CC4C(NC(C)(C)COC5=CC=C(F)C=C5CN1C2=NC3=4)=O)(F)F \|&1:1,r\|

Send Inquriy

Animal Model:	Female SCID/beige mice (5-8 weeks old) bearing Ba/F3 cells^[1]
Dosage:	2 mg/kg, 5 mg/kg, and 10 mg/kg
Administration:	p.o.; twice a day; for 2 weeks
Result:	Caused complete tumor regression in ALK mutation-dependent xenograft models.