6-Fluoro-3,4-dihydro-4-[5-O-[hydroxy[[hydroxy(phosphonooxy)phosphinyl]oxy]phosphinyl]-β-D-ribofuranosyl]-3-oxo-pyrazinecarboxamide Sodium Salt (>75%)
6-Fluoro-3,4-dihydro-4-[5-O-[hydroxy[[hydroxy(phosphonooxy)phosphinyl]oxy]phosphinyl]-β-D-ribofuranosyl]-3-oxo-pyrazinecarboxamide Sodium Salt (>75%)
英文名称:6-Fluoro-3,4-dihydro-4-[5-O-[hydroxy[[hydroxy(phosphonooxy)phosphinyl]oxy]phosphinyl]-β-D-ribofuranosyl]-3-oxo-pyrazinecarboxamide Sodium Salt (>75%)
CAS号:356783-10-3
分子式:C10H16FN3NaO15P3
分子量:553.15
EINECS号:
Mol文件:356783-10-3.mol
![6-Fluoro-3,4-dihydro-4-[5-O-[hydroxy[[hydroxy(phosphonooxy)phosphinyl]oxy]phosphinyl]-β-D-ribofuranosyl]-3-oxo-pyrazinecarboxamide Sodium Salt (>75%) 结构式](https://img.chemicalbook.com/CAS/20211123/GIF/356783-10-3.gif)
6-Fluoro-3,4-dihydro-4-[5-O-[hydroxy[[hydroxy(phosphonooxy)phosphinyl]oxy]phosphinyl]-β-D-ribofuranosyl]-3-oxo-pyrazinecarboxamide Sodium Salt (>75%) 性质
| 熔点 | >123°C (dec.) |
|---|---|
| 储存条件 | Hygroscopic, -20°C Freezer, Under inert atmosphere |
| 溶解度 | 可微溶于水 |
| 形态 | 固体 |
| 颜色 | 淡黄色至淡米色 |
6-Fluoro-3,4-dihydro-4-[5-O-[hydroxy[[hydroxy(phosphonooxy)phosphinyl]oxy]phosphinyl]-β-D-ribofuranosyl]-3-oxo-pyrazinecarboxamide Sodium Salt (>75%) 用途与合成方法
T-705RTP sodium 是一种具有具有选择性和 GTP 竞争性的流感病毒 RNA 聚合酶 (RNA polymerase) 抑制剂，IC50 为 0.14 μM，Ki 为 1.52 μM。T-705RTP sodium 是 T-705 的活性三磷酸盐代谢产物，具有有效的抗流感病毒活性。
T-705RTP sodium and T-705RMP are detected in MDCK cells treated with T-705. T-705RTP sodium inhibits influenza virus RNA polymerase activity in a dose-dependent and a GTP-competitive manner.
T-705RTP sodium inhibits the incorporation of ATP and GTP in a competitive manner with K
i
values of 7.72 and 1.56 μM, respectively. T-705RTP sodium inhibits the incorporation of CTP in a mixed-type manner with a K
i
value of 11.3 μM, and also inhibits the incorporation of UTP in a noncompetitive manner.
The incorporation of a single molecule of T-705RTP sodium (10-1000 μM) inhibits influenza virus RNA strand extension.
6-Fluoro-3,4-dihydro-4-[5-O-[hydroxy[[hydroxy(phosphonooxy)phosphinyl]oxy]phosphinyl]-β-D-ribofuranosyl]-3-oxo-pyrazinecarboxamide Sodium Salt (>75%)供应商 更多
上海皓鸿生物医药科技有限公司
联系电话：400-8210725 4008210725
产品介绍：
中文名称：T-705RTP 纳盐 (>75%)
英文名称：T-705RTP Sodium Salt (>75%)
CAS：356783-10-3
纯度：95%
TargetMol中国（陶术生物）
联系电话： 15002134094
产品介绍：
中文名称：化合物 T-705RTP sodium
英文名称：T-705RTP sodium
CAS：356783-10-3
纯度：98%
包装信息：100mg
