A2764 dihydrochloride - TRESK inhibitor A2764

A2764 (100 µM) inhibits the background K ⁺ current by 42.8±11.5% when it applies to the oocytes expressing mTRESK.A2764 (100 µM) shows an improved inhibitory potency for activated channel with an IC ₅₀ of activated channel in ionomycin-activated mTRESK current.The subsequent application of A2764 strongly inhibits the current (77.8±3.5%). A2764 (100 µM) inhibits the current of TRESK under resting conditions and in the activated state by 42.8±11.5% and 77.8±3.5%, respectively.