Taurohyodeoxycholic acid sodium salt hydrate

Product NameTaurohyodeoxycholic acid sodium salt hydrate
CAS38411-85-7
MFC26H46NNaO6S
MW523.7
EINECS
MOL File38411-85-7.mol

Chemical Properties

storage temp.	Store at -20°C
solubility	DMF: 30 mg/ml,DMF:PBS(pH 7.2)(1:1): 0.5 mg/ml,DMSO: 20 mg/ml,Ethanol: 20 mg/ml
form	A crystalline solid
color	White to off-white
InChIKey	VNQXUJQHLHHTRC-WMWRQJSFSA-M
SMILES	[Na+].[S](=O)(=O)([O-])CCNC(=O)CC[C@H]([C@@H]1[C@@]2([C@H]([C@H]3[C@@H]([C@@]4([C@H]([C@H](C3)O)C[C@@H](CC4)O)C)CC2)CC1)C)C

Safety Information

WGK Germany	3
Storage Class	11 - Combustible Solids

Usage And Synthesis

Description

Taurohyodeoxycholic acid (THDCA) is a taurine-conjugated form of the secondary bile acid hyodeoxycholic acid . THDCA decreases the size and weight of human gallstones in vitro. It increases bile flow, biliary cholesterol secretion, and biliary lipid secretion in rats. Co-administration of THDCA with taurochenodeoxycholic acid (TCDCA; ) prevents TCDCA-induced hepatotoxicity, increasing bile flow as well as biliary acid and phospholipid secretion in rats. THDCA also reduces myeloperoxidase activity, expression of TNF-α and IL-6, and colonic damage in a mouse model of TNBS-induced ulcerative colitis.

Uses

Sodium taurohyodeoxycholate hydrate has been used in a study to assess dose-response data for cytotoxicity, regenerative cell proliferation and secondary oxidative DNA damage in rat livers treated with furan. It has also been used in a study to investigate the use of an immobilized artificial membrane HPLC column to predict bile salt-membrane interactions.

General Description

Sodium taurohyodeoxycholate hydrate is a taurine-amidated bile salt, which can be used as an anionic detergent.

References

[1] M ANGELICO. Dissolution of human cholesterol gallstones in bile salt/lecithin mixtures: effect of bile salt hydrophobicity and various pHs.[J]. Scandinavian Journal of Gastroenterology, 1995, 30 12: 1178-1185. DOI: 10.3109/00365529509101628
[2] M ANGELICO. Effect of taurohyodeoxycholic acid, a hydrophilic bile salt, on bile salt and biliary lipid secretion in the rat.[J]. Digestive Diseases and Sciences, 1994, 39 11: 2389-2397. DOI: 10.1007/bf02087656
[3] ALDO RODA. Taurohyodeoxycholic acid protects against taurochenodeoxycholic acid–induced cholestasis in the rat[J]. Hepatology, 2003, 27 2: 520-525. DOI: 10.1002/hep.510270228
[4] JIAO HE . Protective effect of taurohyodeoxycholic acid from Pulvis Fellis Suis on trinitrobenzene sulfonic acid induced ulcerative colitis in mice[J]. European journal of pharmacology, 2011, 670 1: Pages 229-235. DOI: 10.1016/j.ejphar.2011.08.036

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