Adenosine A1 receptor activator T62 (0.3-3 μg; intrathecal administration; male SpragueDawley rats) treatment produces a dose-dependent antihypersensitivity effect, with no effect on ambulation or activity level[1].
| Animal Model: | Male SpragueDawley rats (250 g) after paw incision surgery[1] |
| Dosage: | 0.3 μg, 0.5 μg, 1 μg, and 3 μg |
| Administration: | Intrathecal administration |
| Result: | Produced a dose-dependent antihypersensitivity effect, with no effect on ambulation or activity level. The ED40 (95% confidence interval) was 0.77 (0.63-0.91) μg.
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