ACE (angiotensin-converting enzyme) can transform angiotensin I (Ang I) into vasoconstrictor molecule angiotensin II (Ang II). It plays an important role in the development of various diseases like systemic lupus erythematosus, hypertension, chronic kidney disease, and diabetic nephropathy. It also plays a major role in the conversion of angiotensin I to an active peptide, angiotensin II.
