5-FAM-Amyloid-β (1-28) Peptide (human) (trifluoroacetate salt)

5-FAM-Amyloid-β (1-28) peptide is a fluorescently labeled peptide. Amyloid-β (1-28) (Aβ28) is a synthetic peptide that lacks 14 C-terminal amino acids and is more soluble than Aβ42.1 Aβ28 forms fibrils and plaques in vitro that are similar to those formed by Aβ42 and induces learning deficits in a passive avoidance task in rats.2,3,4 5-FAM-Amyloid-β (1-28) is a labeled form of Aβ28 containing 5-carboxyfluorescein (5-FAM; Item No. 19581), which displays excitation/emission maxima of 492/518 nm, respectively.WARNING This product is not for human or veterinary use.

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[2] D A KIRSCHNER. Synthetic peptide homologous to beta protein from Alzheimer disease forms amyloid-like fibrils in vitro.[J]. Proceedings of the National Academy of Sciences of the United States of America, 1987, 84 19: 6953-6957. DOI: 10.1073/pnas.84.19.6953
[3] D BURDICK. Assembly and aggregation properties of synthetic Alzheimer’s A4/beta amyloid peptide analogs.[J]. The Journal of Biological Chemistry, 1992, 267 1: 546-554.
[4] X A ALVAREZ. Intrahippocampal injections of the beta-amyloid 1-28 fragment induces behavioral deficits in rats.[J]. Methods and findings in experimental and clinical pharmacology, 1997, 19 7: 471-479.