TFLLR-NH2(TFA)
TFLLR-NH2(TFA) 性质
储存条件 | Store at -20°C |
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溶解度 | 水:100mg/mL(131.26mM);二甲基亚砜:100 mg/mL(131.26 mM) |
形态 | 固体 |
颜色 | 白色至米白色 |
序列 | H-Thr-Phe-Leu-Leu-Arg-NH2 |
TFLLR-NH2(TFA) 用途与合成方法
EC50: 1.9 μM (PAR1)
PAR1 agonists stimulate concentration-dependent increases in [Ca 2+ ]i and in the proportions of neurones. The maximal increase in [Ca 2+ ]i above basal is detected in response to 10 μm TF-NH2 (peak 196.5±20.4 nM, n=25) when 50–80% of identified neurones responded. SW620 cells cultured in the supernatant of TFLLR-NH2-activated platelets upregulate E-cadherin expression and downregulate the vimentin expression. In the in vitro platelet culture system, a TFLLR-NH2 dose-dependent increase of secreted TGF-β1 is detected in the supernatant.
Injection of TF-NH2 into the rat paw stimulates a marked and sustained oedema. An NK1R antagonist and ablation of sensory nerves with capsaicin inhibit oedema by 44% at 1 h and completely by 5 h. In wild-type but not PAR1 −/− mice, TF-NH2 stimulates Evans blue extravasation in the bladder, oesophagus, stomach, intestine and pancreas by 2–8 fold. Extravasation in the bladder, oesophagus and stomach is abolished by an NK1R antagonist. TFp-NH2 produces notable contraction at 3-50 μM and relaxation at 0.3-50 μM, in the absence of apamin. The concentration-response curve for TFp-NH2-induced contraction is remarkably shifted left, when the TFp-NH2-induced relaxation is blocked by apamin at 0.1 μM.
纯度(HPLC) ≥98.0%
醋酸根含量≤12.0%
水分含量≤8.0%
肽含量≥80.0%
内毒素≤50EU/mg
氨基酸组成分析≤±10%
TFLLR-NH2(TFA) 价格(试剂级)
更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
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2024-11-08 | HY-P0226A | 1313730-19-6 | 1313730-19-6 | 1mg | 500 |
2024-11-08 | HY-P0226A | 1313730-19-6 | 1313730-19-6 | 5mg | 1500 |