化合物MN58B
化合物MN58B 用途与合成方法
Choline kinase α (CHKα)
The
IC
50
s of MN58b for parental and Gemcitabine-resistant Suit2 007 cells are 3.14 µM and 0.77 µM, respectively.
MN58b (1-5 µM; 72 hours; SK-PC-1, Suit2 008, IMIM-PC2, and RWP-1 cells) has a marked effect on colony formation at 1 µM, and growth is completely abolished at 5 µM in all the cell lines.
MN58b ((1-10 µM; 24-48 hours; SK-PC-1, Suit2 008, IMIM-PC2, and RWP-1 cells) induces apoptosis and this response correlates with CHKα expression.
Cell Viability Assay
| Cell Line: | SK-PC-1, Suit2 008, IMIM-PC2, and RWP-1 cells |
| Concentration: | 1 µM, 5 µM |
| Incubation Time: | 72 hours |
| Result: | Inhibited cells growth. |
Apoptosis Analysis
| Cell Line: | SK-PC-1, Suit2 008, IMIM-PC2, and RWP-1 cells |
| Concentration: | 1 µM, 2 µM, 5 µM, 10 µM |
| Incubation Time: | 24 and 48 hours |
| Result: | Induced cell apoptosis. |
MN58b (4 mg/kg; intraperitoneal injection; once a day; for 5 days; MF-1 nude mice) treatment significantly decreases phosphomonoesters in both HT29 and MDA-MB-231 xenografts. Phosphocholine levels are found to correlate with choline kinase activities.
| Animal Model: | MF-1 nude mice with HT29 or MDA-MB-231 cells |
| Dosage: | 4 mg/kg |
| Administration: | Intraperitoneal injection; once a day; for 5 days |
| Result: | Phosphomonoesters decreased significantly. |
化合物MN58B 价格(试剂级)
| 更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
|---|---|---|---|---|---|
| 2024-11-08 | HY-108431 | 化合物MN58B | 203192-01-2 | 1mg | 3500 |
| 2023-01-06 | S0998 | 化合物MN58B | 203192-01-2 | 1mg | 6036.03 |
