Methoxy-X04

Methoxy-X04 is a brain-permeable fluorescent probe for amyloid-β (Aβ) to detect and quantify plaques, tangles, and cerebrovascular amyloid. It displays high in vitro binding affinity (K_i = 26.8 nM) for fibrillar β-sheet deposits and is used to image Aβ plaques in the brains of living APP/PS1 mice, a transgenic model of familial Alzheimer''s disease. For in vivo imaging, APP/PS1 mice were injected with methoxy-X04 at a dose of 10 mg/kg, i.p., 24 hours prior to two-photon imaging. Methoxy-X04 displays an excitation peak at 750 nm with emission between 460 and 500 nm.

Methoxy-X04 is a small molecule Aβ-binding agent, which exhibits anti-amyloid effects.

+4°C. Protect from light.

[1] WILLIAM E KLUNK. Imaging Abeta plaques in living transgenic mice with multiphoton microscopy and methoxy-X04, a systemically administered Congo red derivative.[J]. Journal of Neuropathology and Experimental Neurology, 2002, 61 9: 797-805. DOI: 10.1093/jnen/61.9.797
[2] STEFFEN BURGOLD. In vivo multiphoton imaging reveals gradual growth of newborn amyloid plaques over weeks[J]. Acta Neuropathologica, 2010, 121 3: 327-335. DOI: 10.1007/s00401-010-0787-6