endo-BCN-PEG2-alcohol

Product Nameendo-BCN-PEG2-alcohol
CAS1807501-85-4
MFC17H27NO5
MW325.4
EINECS
MOL File1807501-85-4.mol

Chemical Properties

Boiling point	496.9±30.0 °C(Predicted)
Density	1.17±0.1 g/cm3(Predicted)
solubility	Soluble in Water, DMSO, DCM, DMF
form	Oil
pka	12.05±0.46(Predicted)
color	Colorless to light yellow

Usage And Synthesis

Description

endo-BCN-PEG2-alcohol is a click chemistry PEG linker. The BCN group is very reactive with azide-tagged molecules. The hydroxyl group enables further derivatization or replacement with other reactive functional groups.

Uses

endo-BCN-PEG2-alcohol is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. endo-BCN-PEG2-alcohol is a click chemistry reagent, it contains a BCN group that can undergo strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing Azide groups.

IC 50

PEGs

References

[1] An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 DOI:10.1016/j.ebiom.2018.09.005