DeltaMethrin-d5

Deltamethrin-d5 is intended for use as an internal standard for the quantification of deltamethrin (Item No. 24172) by GC- or LC-MS. Deltamethrin is a type II pyrethroid insecticide and a modulator of voltage-gated sodium channels (Nav).1 It activates Nav1.8 channels and induces a tail current delay in Xenopus oocytes expressing the rat channel when used at a concentration of 10 µM. Deltamethrin induces mortality in A. sinensis (LC50 = 4.522 ppm) and T. urticae (LC50 = 0.06 g/L).2,3 It decreases sperm count, motility, and viability and increases the percentage of morphologically abnormal sperm in rats when administered at a dose of 5 mg/kg.4 Formulations containing deltamethrin have been used as domestic and agricultural insecticides.WARNING This product is not for human or veterinary use.

[1] JIN-SUNG CHOI  David M S. Structure–activity relationships for the action of 11 pyrethroid insecticides on rat Nav1.8 sodium channels expressed in Xenopus oocytes[J]. Toxicology and applied pharmacology, 2006, 211 3: Pages 233-244. DOI: 10.1016/j.taap.2005.06.022
[2] KYU-SIK CHANG. Susceptibility and Resistance of Field Populations of Anopheles sinensis (Diptera: Culicidae) Collected from Paju to 13 Insecticides[J]. Osong Public Health and Research Perspectives, 2013, 4 2: Pages 76-80. DOI: 10.1016/j.phrp.2013.02.001
[3] D. PENMAN M B R Chapman. Direct toxicity and repellent activity of pyrethroids against Tetranychus urticae (Acari: Tetranychidae)[J]. Journal of Economic Entomology, 1986, 79 1: 1183-1187. DOI: 10.1093/jee/79.5.1183
[4] F. BEN ABDALLAH. Comparative effects of dimethoate and deltamethrin on reproductive system in male mice[J]. Andrologia, 2010, 42 3: 182-186. DOI: 10.1111/j.1439-0272.2009.00976.x