Fatostatin A

Product NameFatostatin A
CAS125256-00-0
MFC18H18N2S
MW294.41
EINECS
MOL File125256-00-0.mol

Chemical Properties

Boiling point	474.3±55.0 °C(Predicted)
Density	1.125±0.06 g/cm3(Predicted)
storage temp.	under inert gas (nitrogen or Argon) at 2-8°C
solubility	Soluble in DMSO (up to 25 mg/ml).
form	solid
pka	3.46±0.10(Predicted)
color	Yellow
Stability	Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 3 months.

Usage And Synthesis

Description

Fatostatin (125256-00-0) blocks adipogenesis by inhibiting the activation of SREBP. Inhibits the ER-Golgi translocation of SREBPs via binding to their escort protein (SCAP). Fatostatin prevents increases in body weight, blood glucose, and hepatic fat accumulation in obese ob/ob mice.1Inhibits high glucose-induced TGF-β in mesangial cells.2Cell permeable.

Uses

Fatostatin A is Cell permeable inhibitor of SREBP activation.

Definition

ChEBI: 4-(4-methylphenyl)-2-(2-propyl-4-pyridinyl)thiazole is a member of thiazoles.

in vivo

Fatostatin (125B11) (30 mg/kg; 150 μL; i.p. injection; daily for 28 days) reduces adiposity, ameliorated fatty liver by reducing triglyceride (TG) storage, and lowered hyperglycemia in ob/ob mice^[2].

Animal Model:	Four-to-five-week-old homozygous male obese (ob/ob) mice (C57BL/6J)^[2]
Dosage:	30 mg/kg; 150 μL
Administration:	i.p. injection; daily for 28 days
Result:	Blocked increases in body weight, blood glucose, and hepatic fat accumulation in obese ob/ob mice, even under uncontrolled food intake.

References

[1] SHINJI KAMISUKI. A small molecule that blocks fat synthesis by inhibiting the activation of SREBP.[J]. Chemistry & biology, 2009: 882-892. DOI:10.1016/j.chembiol.2009.07.007
[2] LALITA UTTARWAR. SREBP-1 activation by glucose mediates TGF-β upregulation in mesangial cells.[J]. American Journal of Physiology-renal Physiology, 2012, 302 3: F329-41. DOI:10.1152/ajprenal.00136.2011