Prostaglandin D2 (PGD2) binds to two receptor subtypes: DP1 and CRTH2/DP2, which are both membrane-bound G protein-coupled receptors (GPCRs) but do not have significant homology and are differentially expressed.1 The DP1 receptor is expressed in various tissues and cells including the brain, spleen, lungs, bone marrow, stomach, skin, and mast cells.2,3,4 It is coupled to Gαs, and its activation increases intracellular cAMP levels.5 Signaling through the DP1 receptor is involved in inflammation, allergy, and sleep regulation.5,1 Cayman’s DP1 Receptor Polyclonal Antibody can be used for immunofluorescence (IF) and Western blot (WB) applications. The antibody recognizes the DP1 receptor at approximately 41 kDa from human, mouse, and rat samples.WARNING This product is not for human or veterinary use.
