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2-Methyl-4-((triMethylsilyl)ethynyl)thiazole
Product Name
2-Methyl-4-((triMethylsilyl)ethynyl)thiazole
CAS
329203-85-2
MF
C9H13NSSi
MW
195.36
EINECS
MOL File
329203-85-2.mol
Chemical Properties
Boiling point
231℃
Density
1.02
Flash point
93℃
pka
2.72±0.10(Predicted)
Usage And Synthesis
Uses
2-Methyl-4-[2-(trimethylsilyl)ethynyl]-1,3-thiazole (CAS# 329203-85-2) is an intermediate in the synthesis of MTEP Hydrochloride (M759900), a potent mGlu5 receptor antagonist, acting as a negative allosteric modulator.
Preparation Products And Raw materials
Raw materials
1-CHLORO-4-TRIMETHYLSILANYL-BUT-3-YN-2-ONE
4-BROMO-2-METHYLTHIAZOLE
Thioacetamide
Trimethylsilylacetylene
2-Methyl-4-((triMethylsilyl)ethynyl)thiazole Supplier
CONIER CHEM AND PHARMA LIMITED
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