FO-35 is an ionizable cationic lipid (pKa = 7.67) that has been used in the generation of lipid nanoparticles (LNPs) for the delivery of mRNA in vivo.1 Intranasal administration of LNPs containing FO-35 and encapsulating reporter mRNA accumulate in nasal epithelial tissue in mice. Nebulized administration of FO-35-containing LNPs encapsulating Cre mRNA induces the expression of tdTomato in the lungs of ferrets engineered to express tdTomato upon Cre-mediated recombination.WARNING This product is not for human or veterinary use.
References
[1] WITTEN J, RAJI I, MANAN R S, et al. Artificial intelligence-guided design of lipid nanoparticles for pulmonary gene therapy[J]. Nature biotechnology, 2024, 140 1. DOI: 10.1038/s41587-024-02490-y
