Asialoglycoprotein receptor 1 is a calcium-dependent C-type lectin receptor.1 It is composed of a carbohydrate recognition domain, which primarily recognizes galactosides such as D-galactose and N-acetyl-D-galactosamine (GalNAc), stalk region, transmembrane domain, and cytoplasmic domain. Asialoglycoprotein receptor 1 is expressed in hepatocytes and alternative splicing produces both long and short isoforms.2 The long isoform localizes to the cell membrane, while the short isoform exists as a soluble form that is both secreted and found in the cytoplasm. The asialoglycoprotein receptor is a trimer that is commonly formed by two H1 subunits and one H2 subunit.1 It is involved in the clearance of desialylated serum glycoproteins and hepatotropic virus entry via endocytosis. Ectopic expression of the gene encoding asialoglycoprotein receptor 1 (ASGR1) increases binding of hepatitis E virus to cells in vitro.3 Knockdown of ASGR1 increases survival and decreases liver injury and plasma TNF-α and IL-1β levels in a mouse model of sepsis.4 Decreased protein levels of asialoglycoprotein receptor 1 negatively correlate with hepatocellular carcinoma tumor grade.5 The asialoglycoprotein receptor has been used as a target of galactosylated drug conjugates and various lipid-based drug delivery (LBDD) platforms, including lipid nanoparticles (LNPs), liposomes, and micelles, for therapeutic and imaging applications.1 Cayman's Asialoglycoprotein Receptor 1 Extracellular Domain (human, recombinant) protein consists of 246 amino acids and a calculated molecular weight of 28.8 kDa. By SDS-PAGE, under reducing conditions, the apparent molecular mass of the protein is approximately 37 kDa due to glycosylation.WARNING This product is not for human or veterinary use.
