Pentanoic acid, 4-[[4-[[(3-chloro-4-methoxyphenyl)methyl]amino]-5-[[(2-pyrimidinylmethyl)amino]carbonyl]-2-pyrimidinyl]amino]-5-hydroxy-

Avanafil metabolite M16 is a major inactive metabolite of the phosphodiesterase 5 (PDE5) inhibitor avanafil .¹ Avanafil is metabolized by the cytochrome P450 (CYP450) isoforms CYP3A4 and CYP2C to the major metabolites avanafil metabolite M16 and avanafil metabolite M4 , as well as minor metabolites.²

1. Kedia, G.T., ückert, S., Assadi-Pour, F., et al. Avanafil for the treatment of erectile dysfunction: Initial data and clinical key properties Ther. Adv. Urol. 5(1),35-41(2013).
2. Kyle, J.A., Brown, D.A., and Hill, J.K. Avanafil for erectile dysfunction Ann. Pharmacother. 47(10),1312-1320(2013).