Glycine, N-D-γ-glutamyl-, mono(trifluoroacetate) (9CI)

γ-D-Glutamylglycine (γ-DGG) is an antagonist of the excitatory amino acids NMDA , quisqualate, kainate, and glutamate.¹ It decreases the amplitude of excitatory post-synaptic potentials (EPSPs) in electrically stimulated rat hippocampal slices when used at a concentration of 200 mM. Subdural administration of γ-DGG inhibits NMDA-, kainate-, or quisqualate-induced paw biting, indicating antinociceptive activity, in mice (EC₅₀s = 63, 9.5, and 31 μM, respectively).² γ-DGG reduces sound-induced wild running and inhibits the clonic and tonic phases of sound-induced seizures in DBA/2 mice (ED₅₀s = 0.058, 0.046, and 0.054 μmol, i.c.v., respectively).³

1. Crunelli, S., Forda, S., and Kelly, J.S. Blockade of amino acid-induced depolarizations and inhibition of excitatory post-synaptic potentials in rat dentate gyrus J. Physiol. 341,627-640(1983).
2. Raigorodsky, G., and Urca, G. Spinal antinociceptive effects of excitatory amino acid antagonists: Quisqualate modulates the action of N-methyl-D-aspartate Eur. J. Pharmacol. 182(1),37-47(1990).
3. Croucher, M.J., Collins, J.F., and Meldrum, B.S. Anticonvulsant action of excitatory amino acid antagonists Science 216(4548),899-901(1982).