Norhyodeoxycholic acid (NHDCA) is a synthetic bile acid and a derivative of hyodeoxycholic acid (HDCA; ).
1,2 NHDCA is an intermediate in the synthesis of 3β-sulfooxy-7β-hydroxy-24-nor-5-cholen-23-oic acid, which has been used as an internal standard for the quantification of Δ
5-bile acid conjugates that have been identified in patients with Niemann-Pick disease type C1.
3
1. Schteingart, C.D., and Hofmann, A.F. Synthesis of 24-nor-5β-cholan-23-oic acid derivatives: A convenient and efficient one-carbon degradation of the side chain of natural bile acids J. Lipid Res. 29(10),1387-1395(1988).
2. Une, M., and Hoshita, T. Natural occurrence and chemical synthesis of bile alcohols, higher bile acids, and short side chain bile acids Hiroshima J. Med. Sci. 43(2),37-67(1994).
3. Kakiyama, G., Muto, A., Shimada, M., et al. Chemical synthesis of 3β-sulfooxy-7β-hydroxy-24-nor-5-cholenoic acid: An internal standard for mass spectrometric analysis of the abnormal Δ5-bile acids occurring in Niemann-Pick disease Steroids 74(9),766-772(2009).
