1β-Acetoxypolygodial is a sesquiterpenoid that has been found in
T. lanceolata and has antiprotozoal activity.
1,2 It is active against
T. cruzi amastigotes and trypomastigotes (GI
50s = 57.8 and 72 μM, respectively) but not
T. cruzi epimastigotes (GI
50 = >100 μM).
2
1. Deans, R.M., Gardiner, M.G., Horne, J., et al. Isolation and characterization of 1β‐acetoxypolygodial from Tasmannia lanceolata Asian J. Chem. 3(11),1193-1196(2014).
2. Turner, D.N., Just, J., Dasari, R., et al. Activity of natural and synthetic polygodial derivatives against Trypanosoma cruzi amastigotes, trypomastigotes and epimastigotes Nat. Prod. Res. ,(2019).
