Terpendole I

Terpendole I is a fungal metabolite that has been found in A. yamanashiensis.¹ It is a weak inhibitor of acyl-coenzyme A:cholesterol acyltransferase (ACAT; IC₅₀ = 145 μM) and is active against the bacteria B. cereus and B. subtilis (MICs = 100 μg/ml for both) but not S. aureus, P. aeruginosa, or K. pneumoniae (MICs = >200 μg/ml for all) or the fungus C. albicans (MIC = 200 μg/ml).^1,2 It is cytotoxic to HeLa cells with an IC₅₀ value of 52.6 μM.³

Terpendole I, a fungal indoloditerpene, is a ACAT (acyl-CoA: cholesterol acyltransferase) inhibitor (IC50=145 μM)[1].

ChEBI: Terpendole I is an organooxygen compound and an organic heterotricyclic compound.

Microbial Metabolite

1. Tomoda, H., Tabata, N., Yang, D.-J., et al. Terpendoles, novel ACAT inhibitors produced by Albophoma yamanashiensis. III. Production, isolation and structure elucidation of new components J. Antibiot. (Tokyo) 48(8),793-804(1995).
2. Zhao, J.-C., Wang, Y.-L., Zhang, T.-Y., et al. Indole diterpenoids from the endophytic fungus Drechmeria sp. as natural antimicrobial agents Phytochemistry 148,21-28(2018).
3. Nagumo, Y., Motoyama, T., Hayashi, T., et al. Structure-activity relationships of terpendole E and its natural derivatives ChemistrySelect 2(4),1533-1536(2017).