1-Stearoyl-2-Arachidonoyl-d11-sn-glycero-3-PC

1-Stearoyl-2-arachidonoyl-d11-sn-glycero-3-PC (SAPC-d11) is intended for use as an internal standard for the quantification of 1-stearoyl-2-arachidonoyl-sn-glycero-3-PC (Item No. 10009864) by GC- or LC-MS. SAPC is a phospholipid containing stearic acid (Item No. 10011298) and arachidonic acid (Item Nos. 90010 | 90010.1 | 10006607) at the sn-1 and sn-2 positions, respectively. It is a component of LDL and has been found in human stenotic aortic valves and atherosclerotic plaques.1,2 Levels of SAPC are increased in the subepithelial invasive region compared to the superficial region of tumor tissue samples from patients with superficial-type pharyngeal squamous cell carcinoma.3 SAPC unilamellar vesicles have been used as substrates to quantify the activity of secretory phospholipase A2 (sPLA2) in the presence or absence of inhibitors.4 SAPC has also been used in the formation of lipid bilayers to study the effects of lipid composition on bilayer phase transitions.5WARNING This product is not for human or veterinary use.

[1] GINGER L MILNE. Identification and analysis of products formed from phospholipids in the free radical oxidation of human low density lipoproteins.[J]. Journal of Lipid Research, 2005, 46 2: 307-319. DOI: 10.1194/jlr.m400311-jlr200
[2] SATU LEHTI. Modified lipoprotein-derived lipid particles accumulate in human stenotic aortic valves.[J]. PLoS ONE, 2013: e65810. DOI: 10.1371/journal.pone.0065810
[3] SEIJI ISHIKAWA. The Distribution of Phosphatidylcholine Species in Superficial-Type Pharyngeal Carcinoma.[J]. BioMed Research International, 2017: 5387913. DOI: 10.1155/2017/5387913
[4] NILS HELGE SCHEBB. Fast method for monitoring phospholipase A2 activity by liquid chromatography-electrospray ionization mass spectrometry.[J]. Journal of Chromatography A, 2009, 1216 27: 5249-5255. DOI: 10.1016/j.chroma.2009.05.020
[5] KAORI TADA. Pressure effect on the bilayer phase transition of asymmetric lipids with an unsaturated acyl chain[J]. Annals of the New York Academy of Sciences, 2010, 1189 1: 77-85. DOI: 10.1111/j.1749-6632.2009.05203.x