WS-383 free base is a potent, selective and reversible inhibitor of?DCN1-UBC12?interaction, with an?IC50?of 11 nM. WS-383 free base inhibits Cul3/1 neddylation, induces accumulation of p21, p27 and NRF2[1].
References
[1] Wang S, et al. Development of Highly Potent, Selective, and Cellular Active Triazolo[1,5- a]pyrimidine-Based Inhibitors Targeting the DCN1-UBC12 Protein-Protein Interaction.J Med Chem.?2019 Mar 14;62(5):2772-2797. DOI:10.1021/acs.jmedchem.9b00113
