CRF, bovine TFA
中文名称:CRF, bovine TFA
英文名称:CRF, bovine TFA
CAS号:
分子式:C???H???F?N??O??S
分子量:0
EINECS号:
Mol文件:Mol File
CRF, bovine TFA 用途与合成方法
CRF, bovine (TFA) 是一种有效的 CRF 受体激动剂，能够取代 [125I-Tyr]ovine CRF，Ki 值为 3.52 nM。
Ki: 3.52 nM (CRF receptor).
CRF, bovine is a potent agonist of CRF receptor, and displaces [ 125 I-Tyr]ovine CRF with a K i of 3.52 nM. CRF shows pEC 50 s of 11.16, 8.53 and 8.70 for human CRF 1 , human CRF 2 and rat CRF 2α . CRF is released from hypothalamic-pituitary-adrenal (HPA) axis induced by stress, and leads to production of glucocorticoids which down regulate immune responses. CRF also has proinflammatory effects. CRF affects brain microvessel endothelial cells (BMEC) structure or function, CRF (100 nM) significantly increases cAMP in BMEC.
