Pretreatment with (R)-(-)-α-Methylhistamine dihydrobromide (RAMH; 10 mg/kg; i.p.; 60 min before training) reverses Propofol‐induced (25 mg/kg; i.p.; 30 min before training) memory retention[5].
(R)-(-)-α-Methylhistamine dihydrochloride (6.3 mg/kg; i.p.) significantly decreases the steady-state t-MH level in the mouse brain, whereas these compounds produced no significant changes in the HA level[3].
| Animal Model: | Male Sprague‐Dawley rats (10-12 week)[3] |
| Dosage: | 10 mg/kg |
| Administration: | IP; 60 min before training |
| Result: | Reversed propofol‐induced memory retention.
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