Monoclonal Anti-Histone Deacetylase 5 (HDAC5) (mouse IgG1 isotype) is derived from the HDAC5-35 hybridoma produced by the fusion of mouse myeloma cells (NS1) and splenocytes from BALB/c mice immunized with a synthetic peptide. Mammalian HDACs can be divided into three classes according to sequence homology. Class II consists of the yeast Hda1-like proteins HDAC4, HDAC5, HDAC6, HDAC7, HDAC9 and HDAC10. Histone deacetylase 5 (HDAC5) is a histone deacetylase, located on human chromosome 17q21.
Histone deacetylase 5 (HDAC5) promotes progression of the cell cycle, cell proliferation and apoptosis. HDAC5 activity is important for the differentiation of muscle cells by binding, through its N-terminal domain, to the myocyte enhancer factor-2 (Mef2) protein, thus repressing expression of MEF2 downstream genes. Overexpression of HDAC5 in different cancer cells suppresses their growth by induction of apoptosis in a p53-independent manner. Reduced expression of the protein is observed in colon cancer and acute myeloid leukemia.
