Padanamide A is a bacterial metabolite originally isolated from a marine
Streptomyces species.
1 It is active against five strains of
P. falciparum (EC
50s = 160-340 nM), is not cytotoxic to HEK293 or HepG2 human cell lines, but is cytotoxic to Jurkat T lymphocytes with an IC
50 value of approximately 60 μg/ml.
2,3
1. Nam, S.J., Kauffman, C.A., Jensen, P.R., et al. Isolation and characterization of actinoramides A-C, highly modified peptides from a marine Streptomyces sp Tetrahedron 67(35),6707-6712(2011).
2. Cheng, K.-C., Cao, S., Raveh, A., et al. Actinoramide A identified as a potent antimalarial from titration-based screening of marine natural product extracts J. Nat. Prod. 78(10),2411-2422(2015).
3. Williams, D.E., Dalisay, D.S., Patrick, B.O., et al. Padanamides A and B, highly modified linear tetrapeptides produced in culture by a Streptomyces sp. isolated from a marine sediment Org. Lett. 13(15),3936-3939(2011).
