N-Acetyl-DL-2-amino-n-butyric acid

108-24-7

2835-81-6

7211-57-6

General procedure for the synthesis of 2-acetylaminobutyric acid from ethanoic anhydride and DL-2-aminobutyric acid: 1. dissolve 163 g (1.58 mol) of DL-2-aminobutyric acid in an appropriate amount of acetic acid. 2. 242 g (2.37 mol) of acetic anhydride was added slowly and dropwise to the above solution. 3. the reaction mixture was stirred continuously at 100 °C for 2 hours until the reaction was complete. 4. After completion of the reaction, the solvent was removed by vacuum evaporation to give a solid residue. 5. The solid residue was suspended in ethyl acetate and filtered. 6. The filter cake was washed with ether to remove unreacted raw materials and by-products. 7. The target product 2-acetylaminobutyric acid was obtained after drying in a yield of 220 g (95.9% yield). Product characterization data: 1H-NMR (methanol-d4) δ/ppm 0.97 (t, 3H), 1.65-1.93 (m, 2H), 1.99 (s, 3H), 4.29 (q, 1H).