2-methyl-5-{4-[(4-sulfamoylphenyl)amino]phthalazin-1-yl}benzenesulfonamide

CA IX-IN-3 (Compound 27) is a selective and potent carbonic anhydrase IX (CA IX) inhibitor with an IC50 of 0.48 nM[1].

ENPP3 inhibitor is an inhibitor of ectonucleotide pyrophosphatase/phosphodiesterase family member 3 (ENPP3; Ki = 53.7 nM).1 It is selective for ENPP3 over ENPP1, ENPP2, tissue-nonspecific alkaline phosphatase (TNAP), ecto-5′-nucleotidase (CD73), nucleoside triphosphate diphosphohydrolase 1 (NTPDase 1), NTPDase 2, and NTPDase 3. ENPP3 inhibitor also inhibits carbonic anhydrase II (CAII) and CAIX (Kis = 74.7 and 20.3 nM, respectively).

CA Ⅸ: 0.48 nM (IC₅₀)

1.Lee, S.-Y., Namasivayam, V., Boshta, N.M., et al.Discovery of potent nucleotide pyrophosphatase/phosphodiesterase3 (NPP3) inhibitors with ancillary carbonic anhydrase inhibition for cancer (immuno)therapyRSC Med. Chem.12(7)1187-1206(2021)