7-(4-TERT-BUTYLBENZYL)-1,3-DIMETHYL-3,7-DIHYDRO-1H-PURINE-2,6-DIONE

VU0071063 is a potent and selective activator of the inward-rectifier potassium channel (K_ir) 6.2 and sulfonylurea receptor (SUR) 1 (EC₅₀ = 7 μM using whole cell patch clamp electrophysiology). It is selective for SUR1-containing K_ir6.1 or K_ir6.2 channels over SUR2A, K_ir2.1, K_ir2.2, K_ir2.3, K_ir3.1/3/2, and voltage-gated potassium channel 2.1. VU0071063 inhibits glucose-stimulated calcium entry in isolated mouse pancreatic β-cells.

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