Azide-PEG3-Sulfone-PEG3-azide is a PEG linker containing two azide groups. The azide group enables Click Chemistry with groups such as alkynes, DBCO and BCN. The hydrophilic PEG spacer increases solubility in aqueous media.
Azide-PEG3-Sulfone-PEG3-azide is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. Azide-PEG3-Sulfone-PEG3-azide is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
