m-PEG4-Mal

Product Namem-PEG4-Mal
CAS1263044-81-0
MFC16H26N2O7
MW358.39
EINECS
MOL File1263044-81-0.mol

Chemical Properties

storage temp.	-20°C
form	solid or viscous liquid
InChIKey	DOHTYEHHGXSUJO-UHFFFAOYSA-N
SMILES	O=C1C=CC(N1CCC(NCCOCCOCCOCCOC)=O)=O

Safety Information

WGK Germany	WGK 3
Storage Class	11 - Combustible Solids

Usage And Synthesis

Description

m-PEG4-Mal is a PEG linker containing a maleimide group. The maleimide group will react with a thiol group to form a covalent bond, enabling the connection of biomolecule with a thiol. The hydrophilic PEG spacer increases solubility in aqueous media.

Uses

m-PEG4-amino-Mal is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

reaction suitability

reactivity: thiol reactive
reagent type: chemical modification reagent
reagent type: cross-linking reagent
reactivity: sulfhydryl reactive

IC 50

PEGs

References

[1] An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 DOI:10.1016/j.ebiom.2018.09.005