UNC9994 is a β-arrestin-biased dopamine D? receptor agonist (β-arrestin EC50 = 50 nM; Emax = 97%). UNC9994 has robust in vivo antipsychotic drug-like activities. Functionally selective G protein-coupled receptor (GPCR) ligands, which differentially modulate canonical and noncanonical signaling, are extremely useful for elucidating key signal transduction pathways essential for both the therapeutic actions and side effects of drugs.
![5-(3-(4-(2,3-dichlorophenyl)piperidin-1-yl)propoxy)benzo[d]thiazole Structure](/CAS/20180703/GIF/1354030-51-5.gif)