UBE2E3 (ubiquitin-conjugating enzyme E2E 3) gene is mapped to human chromosome 2q32.1 and encodes a human class III ubiquitin-conjugating enzyme (E2s). It interacts with Nedd4-2, an E3 enzyme, to regulate the epithelial Na+ channel (ENaC) th at functions in the maintenance of Na+ homeostasis and blood pressure. Overexpression of this protein affects Na+ transport. It functions in modulating the balance between proliferation and differentiation of retinal pigment epithelial cells.