MPP 二盐酸盐
中文名称:MPP 二盐酸盐
英文名称:Methyl-piperidino-pyrazole hydrate
CAS号:911295-24-4
分子式:C29H32ClN3O3
分子量:506.04
EINECS号:
Mol文件:911295-24-4.mol
MPP 二盐酸盐 用途与合成方法
MPP dihydrochloride 是一种高度选择性的雌激素受体 α (ERα) 拮抗剂。MPP dihydrochloride 降低了 p-ERα/ERα 的比率。
MPP (1, 5, 10, 25, 50 and 100 µM; 24 h) decreases cell viability with an IC
50
value of 20.01 µM in RL95-2 cells.
MPP dihydrochloride shows antiproliferative activity at a concentration of 10 μM in RL95-2 cells.
MPP dihydrochloride (20 µM; 24 h) reduces the phosphorylation of ERα, while it does not alter the phosphorylation of Akt. MPP dihydrochloride reduces the ratio of p-ERα/ERα.
Cell Viability Assay
| Cell Line: | RL95-2 endometrium cancer cells |
| Concentration: | 1, 5, 10, 25, 50 and 100 µM |
| Incubation Time: | 24 hours |
| Result: | The treatment with 25 µM, 50 µM and 100 µM for 24 h decreased cell viability significantly. However, cell viability was not significantly changed by MPP dihydrochloride at concentration below 25 µM. |
Cell Proliferation Assay
| Cell Line: | RL95-2 cell |
| Concentration: | 10, 15, 20 and 25 µM |
| Incubation Time: | 72 hours |
| Result: | Showed antiproliferative activity at a concentration of 10 μM. |
Western Blot Analysis
| Cell Line: | RL95-2 cell line |
| Concentration: | 20 µM |
| Incubation Time: | 24 hours |
| Result: | Reduced the phosphorylation of ERα, while it did not alter the phosphorylation of Akt. Reduced the ratio of p-ERα/ERα compared to the control group. |
MPP (Low dose 20 μg/kg body weight or high dose 200 μg/kg body weight) leads to a dose-dependent attenuation of percent prepulse inhibition (PPI).
| Animal Model: | Male C57BL/6N mice at the age of 9-10 weeks |
| Dosage: | Low dose (20 μg/kg body weight) or high dose (200 μg/kg body weight) |
| Administration: | Administered subcutaneously (s.c.) injected; injection volume of 5 mL/kg; 60 min before PPI testing |
| Result: | Led to a dose-dependent attenuation of percent PPI. Pretreatment with 200 μg/kg reduced the mean percent PPI scores by ~30%. |
MPP 二盐酸盐供应商 更多
Sigma-Aldrich西格玛奥德里奇(上海)贸易有限公司
联系电话：021-61415566 800-8193336
产品介绍：
英文名称：MPP
CAS：911295-24-4
纯度：>=97% (HPLC)
包装信息：10mg, 25mg
备注：M7068
上海楼岚生物科技有限公司
联系电话：021-52996696，15000506266 15000506266
产品介绍：
英文名称：MPP dihydrochloride
CAS：911295-24-4
纯度：98% HPLC
包装信息：5mg，10mg，50mg，100mg，1g，5g
上海超岚化工科技中心
联系电话：021-QQ：65489617 15618227136
产品介绍：
中文名称：MPP二盐酸盐
英文名称：MPP dihydrochloride
CAS：911295-24-4
纯度：98%
包装信息：5MG;10MG;50MG;100MG,1G,5G,100G
深圳市祥根生物医药有限公司
联系电话：0755-28967200 13631290199
产品介绍：
中文名称：MPP Dihydrochloride
英文名称：MPP Dihydrochloride
CAS：911295-24-4
纯度：99% HPLC or More
包装信息：1MG;10MG;100MG
备注：其它信息：现货产品5M;10MG;50MG;100MG;1G等,其他包装可咨询
成都诺维尔生物医药有限公司
联系电话：028-85255396 18302801538
产品介绍：
中文名称：MPP dihydrochloride中间体
英文名称：4,4'-(4-methyl-5-(4-(2-(piperidin-1-yl)ethoxy)phenyl)-1H-pyrazole-1,3-diyl)diphenol dihydrochloride
CAS：911295-24-4
纯度：98%+
包装信息：1g;5g;10g
最新发布供应信息
MPP Dihydrochloride
深圳市祥根生物医药有限公司
2024-12-18
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TargetMol中国（陶术生物）
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