1-hexadecyl-2-azelaoyl-sn-glycero-3-phosphocholine

Product Name1-hexadecyl-2-azelaoyl-sn-glycero-3-phosphocholine
CAS354583-69-0
MFC33H67N2O8P
MW650.867441
EINECS
MOL File354583-69-0.mol

Chemical Properties

storage temp.	-20°C
solubility	DMF: 33 mg/ml; DMSO: 8 mg/ml; Ethanol: 20 mg/ml; PBS (pH 7.2): 10 mg/ml

Usage And Synthesis

Uses

Azelaoyl-PAF may be used to study its binding affinity with?4F or 2F anti-inflammatory peptides.

Uses

Azelaoyl-PAF may be used in binding assay of anti-inflammatory peptides, 2F and 4F.

Definition

ChEBI: 1-O-hexadecyl-2-(8-carboxyoctanoyl)-sn-glycero-3-phosphocholine is a 2-acyl-1-alkyl-sn-glycero-3-phosphocholine in which the alkyl and the acyl groups at positions 1 and 2 are specified as hexadecyl and 8-carboxyoctanoyl respectively. It has a role as a PPARgamma agonist. It is functionally related to a nonanedioic acid. It is a conjugate acid of a 1-O-hexadecyl-2-(8-carboxyoctanoyl)-sn-glycero-3-phosphocholine(1-).

General Description

1-hexadecyl-2-azelaoyl-sn-glycero-3-phosphocholine (Azelaoyl-PAF) Azelaoyl-PAF is an alkyl phosphatidylcholine and is a component of the lipid pool within oxidized low-density lipoprotein (oxLDL) particles. Azelaoyl-PAF is a low molecular weight phospholipid.

Biochem/physiol Actions

Azelaoyl-PAF (1-hexadecyl-2-azelaoyl-sn-glycero-3-phosphocholine) is a low molecular weight alkyl phosphatidylcholine. It is a constituent of the lipid pool within oxidized low-density lipoprotein (oxLDL) particles. Azelaoyl-PAF serves as a high affinity ligand and agonist for peroxisome proliferator-activated receptor-γ (PPARγ).