Telomeric repeat binding factor (TRF2) is a ubiquitously expressed protein that is implicated in the control of telomere length.1 TRF2, like TRF1, contains a Myb-related DNA binding motif. It binds to duplex TTAGGG repeats and is localized to all human telomeres in metaphase chromosomes.1 TRF2 is thought to protect chromosome ends by maintaining the correct structure at telomere termini.2 The use of mutant forms of TRF2 has implicated a role of TRF2 in the prevention of senescence in primary human cells.2 Inhibition of TRF2 results in apoptosis in a subset of mammalian cell types.3WARNING This product is not for human or veterinary use.
