20-hydroxy N-Arachidonoyl Taurine

Arachidonic acid is metabolized by cytochrome P450 (CYP450) 4A ω-hydroxylase to 20-HETE, which acts as a vasoconstrictor in the kidney and brain.1 During mass spectrometry lipidomics analysis of rat brain, a series of fatty acyl amides of taurine was discovered, of which arachidonoyl taurine is a prominent member.2 20-hydroxy N-Arachidonoyl taurine is a potential CYP450 metabolite of N-arachidonoyl taurine and may activate members of the transient receptor potential (TRP) family of calcium channels.3WARNING This product is not for human or veterinary use.

[1] J C MCGIFF  J Q. 20-HETE and the kidney: resolution of old problems and new beginnings.[J]. American Journal of Physiology, 1999, 277 3: R607-23. DOI: 10.1152/ajpregu.1999.277.3.r607
[2] De Souza, F.I., Zumiotti, A.V., and Da Silva, C.F. Neuregulins 1-α and 1-β on the regeneration the peripheral nerves[J]. Acta Ortop Bras.
[3] ALAN SAGHATELIAN. A FAAH-Regulated Class of N-Acyl Taurines That Activates TRP Ion Channels†[J]. Biochemistry Biochemistry, 2006, 45 30: 9007-9015. DOI: 10.1021/bi0608008