(±)14(15)-EET-d11

(±)14(15)-EET-d11 is intended for use as an internal standard for the quantification of (±)14(15)-EET (Item No. 50651) by GC- or LC-MS. 14(S),15(R)-EET and 14(R),15(S)-EET are formed via epoxidation of arachidonic acid (Item Nos. 90010 | 90010.1 | 10006607) by a variety of cytochrome P450 (CYP) isoforms.1 14(S),15(R)-EET is produced at a higher proportion by CYP2C23, whereas 14(R),15(S)-EET is produced at a greater proportion by CYP2B2 and CYP2C24.WARNING This product is not for human or veterinary use.

[1] J H CAPDEVILA  R C H  J R Falck. Cytochrome P450 and arachidonic acid bioactivation. Molecular and functional properties of the arachidonate monooxygenase.[J]. Journal of Lipid Research, 2000, 41 2: 163-181.
[2] DONG CHENG. MGAT2 inhibitor decreases liver fibrosis and inflammation in murine NASH models and reduces body weight in human adults with obesity.[J]. Cell metabolism, 2022, 34 11: 1732-1748.e5. DOI: 10.1016/j.cmet.2022.10.007