N-(Adamant-1-yl)-6-isopropyl-4-oxo-1-pentyl-1,4-dihydroquinolin-3-carboxamide

SER-601 is a potent and selective peripheral cannabinoid (CB₂) receptor agonist with 190-fold selectivity for CB₂ over the central CB₁ receptor (K_is = 6.3 and 1,220 nM, respectively). At 3 mg/kg, SER-601 has analgesic effects in a formalin-induced nocifensive study in mice without cannabis-like behavioral effects due to its low affinity for the CB₁ receptor. SER-601 also has antidiabetic effects. Two to four week exposure to SER-601 ameliorates insulin resistance in vivo and increases insulin secretion and accumulation in pancreatic islets isolated from high-fat diet/streptozotocin (HFD/STZ)-induced diabetic mice.

SER-601 is a 4-quinolone-3-carboxylic acid derivative and a selective cannabinoid CB2 receptor agonist (1,2,3). It exhibits analgesic and neuroprotective properties.