(1S)-1-[2-[4-[4-(AMINOCARBONYL)PHENYL]-1-PIPERAZINYL]ETHYL]-3,4-DIHYDRO-N-METHYL-1H-2-BENZOPYRAN-6-CARBOXAMIDE
(1S)-1-[2-[4-[4-(AMINOCARBONYL)PHENYL]-1-PIPERAZINYL]ETHYL]-3,4-DIHYDRO-N-METHYL-1H-2-BENZOPYRAN-6-CARBOXAMIDE
英文名称:(1S)-1-[2-[4-[4-(AMINOCARBONYL)PHENYL]-1-PIPERAZINYL]ETHYL]-3,4-DIHYDRO-N-METHYL-1H-2-BENZOPYRAN-6-CARBOXAMIDE
CAS号:187665-65-2
分子式:C24H30N4O3
分子量:422.52
EINECS号:
Mol文件:187665-65-2.mol
(1S)-1-[2-[4-[4-(AMINOCARBONYL)PHENYL]-1-PIPERAZINYL]ETHYL]-3,4-DIHYDRO-N-METHYL-1H-2-BENZOPYRAN-6-CARBOXAMIDE 性质
沸点 | 652.5±55.0 °C(Predicted) |
---|---|
密度 | 1?+-.0.06 g/cm3(Predicted) |
储存条件 | Store at +4°C |
溶解度 | 在 DMSO 中溶解度为 100 mM |
形态 | 粉末 |
酸度系数(pKa) | 15.27±0.40(Predicted) |
颜色 | 白色至米白色 |
(1S)-1-[2-[4-[4-(AMINOCARBONYL)PHENYL]-1-PIPERAZINYL]ETHYL]-3,4-DIHYDRO-N-METHYL-1H-2-BENZOPYRAN-6-CARBOXAMIDE 用途与合成方法
PNU-142633 是一种高亲和力,选择性和口服活性的 5-HT1D 激动剂,对人 5-HT1D 受体和人 5-HT1B 受体的 Ki 分别为 6 nM 和 >18 000 nM。PNU-142633 具有抗偏头痛功效。
5-HT 1D Receptor 6 nM (Ki) |
The intrinsic activity of PNU-142633 at the human 5-HT1D receptor is determined to be 70% that of 5-HT in a cytosensor cell-based assay compared with 84% for that of Sumatriptan.
PNU-142633 (0.03-1 mg/kg; intravenous injection; male Hartley guinea pigs) treatment blocks neurogenic plasma protein extravasation. And PNU-142633 fails to alter resistance in these vascular beds.
Animal Model: | Male Hartley guinea pigs (250-300 g) stimulated with bipolar electrode |
Dosage: | 0.03 mg/kg, 0.1 mg/kg, 0.3 mg/kg, 1 mg/kg |
Administration: | Intravenous injection |
Result: | Significantly reduced extravasation at the 0.1 and 0.3 mg/kg doses, but was without effect at the 0.03 and 1.0 mg/kg doses. |
(1S)-1-[2-[4-[4-(AMINOCARBONYL)PHENYL]-1-PIPERAZINYL]ETHYL]-3,4-DIHYDRO-N-METHYL-1H-2-BENZOPYRAN-6-CARBOXAMIDE 价格(试剂级)
更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
---|---|---|---|---|---|
2024-04-30 | HY-103131 | 1 mg | 2937 | ||
2024-04-30 | HY-103131 | 10 mM * 1 mLin DMSO | 5461 |
(1S)-1-[2-[4-[4-(AMINOCARBONYL)PHENYL]-1-PIPERAZINYL]ETHYL]-3,4-DIHYDRO-N-METHYL-1H-2-BENZOPYRAN-6-CARBOXAMIDE供应商 更多
武汉易泰科技有限公司上海分公司
联系电话:821-50328103-801 18930552037
产品介绍:
英文名称:PNU 142633;(1S)-1-[2-[4-[4-(AMinocarbonyl)phenyl]-1-piperazinyl]ethyl]-3,4-dihydro-N-Methyl-1H-2-benzopyran-6-carboxaMide
CAS:187665-65-2
纯度:99% HPLC
包装信息:1Mg ; 5Mg;10Mg ;100Mg;250Mg ;500Mg ;1g;2.5g ;5g ;10g
安耐吉化学&3A(安徽泽升科技有限公司)
联系电话:021-58432009 400-005-6266
产品介绍:
英文名称:PNU142633
CAS:187665-65-2
纯度:NULL
包装信息:10mg;25mg
备注:NULL
成都超九八生物科技有限公司
联系电话:13348960310 13348960310
产品介绍:
英文名称:PNU-142633
CAS:187665-65-2
纯度:98%
包装信息:5mg;10mg;20mg;50mg;100mg;200mg