2'(3')-O-(5-Bromoanthraniloyl)inosine-5'-O-triphosphate (sodium salt)

2'-O-(5-Bromoanthraniloyl)inosine-5'-O-triphosphate (2'-bromo ANT-ITP) and 3'-bromo ANT-ITP are fluorescent ITP derivatives, which undergo spontaneous isomerization.1 2'(3')-bromo ANT-ITP displays excitation/emission maxima of 345/427 nm, respectively, in water. 2'-bromo ANT-ITP selectively inhibits mammalian adenylyl cyclase (AC1), AC2, and AC5 over B. pertussis AC toxin CyaA (Kis = 7, 22, 4.6, and 920 nM, respectively).WARNING This product is not for human or veterinary use.

[1] JENS GEDUHN. Bis-halogen-anthraniloyl-substituted nucleoside 5’-triphosphates as potent and selective inhibitors of Bordetella pertussis adenylyl cyclase toxin.[J]. Journal of Pharmacology and Experimental Therapeutics, 2011, 336 1: 104-115. DOI: 10.1124/jpet.110.174219