FTase Inhibitor II (trifluoroacetate salt)

FTase Inhibitor II is a cell-permeable analog of FPP that potently inhibits FTase (IC50 = 50-75 nM), preventing farnesylation of Ras.1 It does not inhibit geranylgeranyl transferase at similar concentrations (IC50 > 100 µM).1 FTase Inhibitor II displays no toxicity to untransformed cells but blocks Ras-mediated transformation of NIH 3T3 cells.1WARNING This product is not for human or veterinary use.

[1] VEERASWAMY MANNE. Ras farnesylation as a target for novel antitumor agents: Potent and selective farnesyl diphosphate analog inhibitors of farnesyltransferase[J]. Drug Development Research, 1995, 34 2: 121-137. DOI: 10.1002/ddr.430340205