Negamycin (hydrochloride)

Negamycin is an antibiotic originally found in Streptomyces.1 It is active against various species of bacteria, including E. coli, S. typhosa, and K. pneumoniae, when used at concentrations ranging from 3.12 to 100 µg/ml. Negamycin (250 μM) stabilizes the interaction between tRNA and ribosomes and decreases the rate of mRNA translation.2 It also restores the auditory brainstem response to sound tones in a dystrophin-deficient mdx mouse model of Duchenne muscular dystrophy (DMD) when administered at a dose of 100 mg/kg.3WARNING This product is not for human or veterinary use.

[1] M HAMADA. A new antibiotic, negamycin.[J]. Journal of Antibiotics, 1970, 23 3: 170-171. DOI: 10.7164/antibiotics.23.170
[2] YURY S POLIKANOV. Negamycin interferes with decoding and translocation by simultaneous interaction with rRNA and tRNA.[J]. Molecular Cell, 2014: 541-550. DOI: 10.1016/j.molcel.2014.09.021
[3] MASAYUKI ARAKAWA. Negamycin restores dystrophin expression in skeletal and cardiac muscles of mdx mice.[J]. Journal of biochemistry, 2003, 134 5: 751-758. DOI: 10.1093/jb/mvg203