Streptazolin is a fungal metabolite originally isolated from
S. viridochromogenes.
1 It increases NF-κB activity when used at concentrations ranging from 60 to 130 μg/ml, at least in part,
via PI3K signaling.
2 Streptazolin enhances TNF-α secretion induced by LPS and enhances IL-8 secretion when used alone or in combination with LPS in THP-1 Blue cells.
1. Drautz, H., Zaehner, H., Kupfer, E., et al. Metabolic products of microorganisms. 205. Isolation and structure of streptazolin Helv. Chim. Acta. 64(6),1752-1765(1981).
2. Perry, J.A., Koteva, K., Verschoor, C.P., et al. A macrophage-stimulating compound from a screen of microbial natural products J. Antibiot. (Tokyo) 68(1),40-46(2015).
