Acetamide, 2-[(2-furanylmethyl)[(2-nitrophenyl)methyl]amino]-N-phenyl-

Z164597606 is a selective BChE inhibitor (IC50: 1.3 and 1.7 μM for eqBChE and hBChE). Z164597606 forms a π-π stacking interaction with the amino acid Trp82 of hBChE. Z164597606 can be used for the research of Alzheimer’s disease (AD)[1][2].

eqBCHE: 1.3 μM (IC₅₀); hBCHE: 1.7 μM (IC₅₀)

[1] Xin Lu, et al. Expansion of the scaffold diversity for the development of highly selective butyrylcholinesterase (BChE) inhibitors: Discovery of new hits through the pharmacophore model generation, virtual screening and molecular dynamics simulation. Bioorg Chem. 2019 Apr;85:117-127. DOI:10.1016/j.bioorg.2018.12.023
[2] Xin Lu, et al. Design, synthesis, and biological evaluation of aromatic tertiary amine derivatives as selective butyrylcholinesterase inhibitors for the treatment of Alzheimer's disease. Eur J Med Chem. 2022 Sep 2;243:114729. DOI:10.1016/j.ejmech.2022.114729