Vasonatrin Peptide (VNP)

Chemical Properties

Density	1.47±0.1 g/cm3(Predicted)
Sequence	Gly-Leu-Ser-Lys-Gly-Cys-Phe-Gly-Leu-Lys-Leu-Asp-Arg-Ile-Gly-Ser-Met-Ser-Gly-Leu-Gly-Cys-Asn-Ser-Phe-Arg-Tyr (Disulfide bridge: Cys6-Cys22)

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Animal Model:	High-fat diet-fed streptozotocin-induced diabetic Sprague-Dawley rats^[3]
Dosage:	100 μg/kg
Administration:	I.v. ; 10 min before reperfusion
Result:	Significantly improved the instantaneous first derivation of left ventricle pressure (±LV dP/d_tmax) and LV systolic pressure and reduced LV end-diastolic pressure, apoptosis index, caspase-3 activity, plasma creatine kinase (CK), and lactate dehydrogenase (LDH) activities. Inhibited endoplasmic reticulum (ER) stress by suppressing glucose-regulated protein 78 (GRP78) and C/EBP homologous protein (CHOP).