2-chloro-5-aminomethylthiazole

120740-09-2

120740-08-1

General procedure for the synthesis of (2-chlorothiazol-5-yl)methanamine using 2-((2-chlorothiazol-5-yl)methyl)isodihydroindole-1,3-dione as starting material: 25.3 g of the above off-white solid and 150 mL of ethanol were added to a 250 mL three-necked flask in a unit equipped with a magnetic stirrer, a condenser tube and a drying tube. 9.1 g of hydrazine hydrate was slowly added dropwise to the reaction system. Subsequently, the reaction mixture was heated to reflux for 4-6 hours. Upon completion of the reaction, the solvent was evaporated under reduced pressure to afford 9.1 g of (2-chlorothiazol-5-yl)methylamine, the product was in the form of an orange oil.