Mal-PEG4-amine TFA salt

Product NameMal-PEG4-amine TFA salt
CAS2512227-13-1
MFC16H25F3N2O8
MW430.38
EINECS
MOL File2512227-13-1.mol

Chemical Properties

form	Liquid
color	Colorless to light yellow

Usage And Synthesis

Uses

Mal-PEG4-C2-NH2 TFA is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

Biological Activity

Mal-PEG4-C2-NH2 TFA is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].

IC 50

PEGs

References

[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562